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- Title
Optimal Positive End-Expiratory Pressure During Pumpless Extracorporeal Lung Membrane Support.
- Authors
Jungebluth, Philipp; Iglesias, Manuela; Go, Tetsuhiko; Sibila, Oriol; Macchiarini, Paolo
- Abstract
The aim of this study was to determine the optimal positive end-expiratory pressure (PEEP) required during extracorporeal lung membrane support (interventional lung assist [iLA]; Novalung GmbH, Hechingen, Germany). Twenty healthy pigs were initially (4 h) mechanically ventilated with a tidal volume (VT) of 10 mL/Kg, respiratory rate (RR) of 20 breaths/min, PEEP of 5 cm H2O, and fraction of inspired O2 (FiO2) of 1.0. Thereafter, the iLAs were placed arteriovenously transfemorally and settings reduced to reach near static ventilation (VT ≤ 2 mL/Kg, RR 4 breaths/min, PEEP of 5, FiO2 1.0). Then, animals were assigned to four study groups evaluating 5 cm H2O increasing levels of PEEP for 8 h. Gas exchanges with PEEP ≤ 10 cm H2O were significantly worse than those with PEEP > 12 cm H2O, and this without hemodynamical imbalance. This study suggests that the iLA may provide adequate gas exchange during static ventilation only with PEEP levels > 10 cm H2O, and this without pulmonary or systemic hemodynamic imbalance.
- Subjects
BIOLOGICAL membranes; LUNGS; RESPIRATION; MEDICINE; HEALTH
- Publication
Artificial Organs, 2008, Vol 32, Issue 11, p885
- ISSN
0160-564X
- Publication type
Article
- DOI
10.1111/j.1525-1594.2008.00646.x