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- Title
MicroRNAs and Glial Cell Development.
- Authors
Zheng, Kang; Li, Hong; Huang, Hao; Qiu, Mengsheng
- Abstract
Mounting evidence indicates that microRNAs (miRNAs) play important roles in the control of glial cell development in the central nervous system. Suppression of miRNA formation disrupts the initial generation of oligodendrocyte progenitor cells from the ventricular neuroprogenitor cells in the embryonic spinal cord. miRNAs also regulate the later events of oligodendrocyte development, including cell proliferation, maturation, and myelin formation. In addition, miRNAs are essential for the development of astrocytes, and inhibition of miRNA genesis completely blocks astrogliogenesis in the spinal cord.
- Subjects
MICRORNA; CENTRAL nervous system diseases; CELL proliferation; ASTROCYTES; SPINAL cord
- Publication
Neuroscientist, 2012, Vol 18, Issue 2, p114
- ISSN
1073-8584
- Publication type
Article
- DOI
10.1177/1073858411398322