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- Title
Role of Mitochondrial Amyloid-β in Alzheimer's Disease.
- Authors
Chen, John Xi; Yan, Shirley Shidu
- Abstract
Mitochondrial dysfunction is an early feature of Alzheimer's disease (AD). Abnormalities in mitochondrial properties include impaired energy metabolism, defects in key respiratory enzyme activity/function, accumulation/generation of mitochondrial reactive oxygen species, and formation of membrane permeability transition pore. While the mechanisms underlying mitochondrial dysfunction remain incompletely understood, recent studies provide substantial evidence for the progressive accumulation of mitochondrial Aβ, which directly links to mitochondria-mediated toxicity. In this review, we describe recent studies addressing the following key questions: 1) Does Aβ accumulate in mitochondria of AD brain and AD mouse models?; 2) How does Aβ gain access to the mitochondria?; 3) If mitochondria are loaded with Aβ, do they develop similar evidence of dysfunction?; 4) What are the mechanisms underlying mitochondrial Aβ-induced neuronal toxicity?; and 5) What is the impact of interaction of mitochondrial Aβ with its binding partners (cyclophilin D and ABAD) on mitochondrial and neuronal properties/function in an Aβ milieu? The answers to these questions provide new insights into mechanisms of mitochondrial stress related to the pathogenesis of AD and information necessary for developing therapeutic strategy for AD.
- Subjects
ALZHEIMER'S disease; AMYLOID beta-protein; MITOCHONDRIA; CYCLOPHILINS; REACTIVE oxygen species
- Publication
Journal of Alzheimer's Disease, 2010, Vol 20, p569
- ISSN
1387-2877
- Publication type
Article
- DOI
10.3233/JAD-2010-100357