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- Title
Action mechanism of corticosteroids to aggravate Guillain-Barré syndrome.
- Authors
Wang, Yu-Zhong; Lv, Hui; Shi, Qi-Guang; Fan, Xu-Tao; Li, Lei; Yi Wong, Anna Hiu; Hao, Yan-Lei; Si, Chuan-Ping; Li, Cui-Lan; Yuki, Nobuhiro
- Abstract
Corticosteroids have been proved to be ineffective for Guillain-Barré syndrome, but the mechanism remains unknown. In a rabbit model of axonal Guillain-Barré syndrome, treatment with corticosteroids significantly reduced macrophage infiltration in the spinal ventral roots and the survival rate as well as clinical improvement. On 30th day after onset, there was significantly higher frequency of axonal degeneration in the corticosteroids-treated rabbits than saline-treated rabbits. Corticosteroids may reduce the scavengers that play a crucial role for nerve regeneration, thus delay the recovery of this disease.
- Subjects
PHYSIOLOGICAL effects of adrenocortical hormones; PHYSIOLOGICAL effects of steroid hormones; GUILLAIN-Barre syndrome; AXONAL transport; NERVOUS system regeneration; GENETICS
- Publication
Scientific Reports, 2015, p13931
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep13931