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- Title
The Metabotropic Glutamate 5 Receptor in Sleep and Wakefulness: Focus on the Cortico-Thalamo-Cortical Oscillations.
- Authors
Ngomba, Richard Teke; Lüttjohann, Annika; Dexter, Aaron; Ray, Swagat; van Luijtelaar, Gilles
- Abstract
Sleep is an essential innate but complex behaviour which is ubiquitous in the animal kingdom. Our knowledge of the distinct neural circuit mechanisms that regulate sleep and wake states in the brain are, however, still limited. It is therefore important to understand how these circuits operate during health and disease. This review will highlight the function of mGlu5 receptors within the thalamocortical circuitry in physiological and pathological sleep states. We will also evaluate the potential of targeting mGlu5 receptors as a therapeutic strategy for sleep disorders that often co-occur with epileptic seizures.
- Subjects
GLUTAMATE receptors; SLEEP; OSCILLATIONS; EPILEPSY; NEURAL circuitry; WAKEFULNESS; NON-REM sleep
- Publication
Cells (2073-4409), 2023, Vol 12, Issue 13, p1761
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells12131761