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- Title
Molecular Biology in Glioblastoma Multiforme Treatment.
- Authors
Abbruzzese, Claudia; Persico, Michele; Matteoni, Silvia; Paggi, Marco G.
- Abstract
To sum up, increased CD8+ tumor-reactive proliferating T cells and their ability to interfere with the immunoregulatory effects of IFN in the tumor microenvironment provide the patient with a better prognosis, as evaluated via OS. In GBM patients, relapse is almost always guaranteed, thus dictating patient prognosis. Glioblastoma (GBM, grade IV astrocytoma), the most frequently occurring primary brain tumor, presents unique challenges to therapy due to its location, aggressive biological behavior, and diffuse infiltrative growth, thus contributing to having disproportionately high morbidity and mortality. Shi and collaborators [[18]] describe the importance of the tumor microenvironment in cancer progression and focus on the role of Fibroblast Activation Protein (FAP) in evading immune surveillance in GBM patients.
- Subjects
GLIOBLASTOMA multiforme; MOLECULAR biology; BEVACIZUMAB
- Publication
Cells (2073-4409), 2022, Vol 11, Issue 11, p1850
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells11111850