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- Title
Association between alcohol consumption and diabetic retinopathy and visual acuity—the AdRem Study.
- Authors
Lee, C. C.; Stolk, R. P.; Adler, A. I.; Patel, A.; Chalmers, J.; Neal, B.; Poulter, N.; Harrap, S.; Woodward, M.; Marre, M.; Grobbee, D. E.; Beulens, J. W.
- Abstract
Diabet. Med. 27, 1130–1137 (2010) Aims We investigated the association between alcohol consumption and diabetic retinopathy and deterioration of visual acuity in individuals with Type 2 diabetes. Methods We conducted a cohort analysis of 1239 participants with Type 2 diabetes aged 55–81 years enrolled in the AdRem study, a sub-study of the Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation (ADVANCE) trial. Current and past consumption of wine, spirits and beer was measured by self-report. Moderate and heavy alcohol consumption was defined as 1–14 and > 14 drinks/week, respectively. Diabetic retinopathy, measured by mydriatic stereoscopic seven-field retinal photography, was defined by a 2-step progression in the Early Treatment of Diabetic Retinopathy Study (ETDRS) score or the presence of any retinal vascular lesions. Deterioration of visual acuity was defined by a decrease of two lines in best vision in either eye, measured corrected, or through a pinhole using a Snellen chart. Results In a mean follow-up of 5.5 years, we identified 182 participants with a 2-step progression in the ETDRS score, 640 participants with the presence of any retinal vascular lesions and 693 participants with a deterioration of visual acuity. Current moderate consumption of alcohol, compared with no current consumption, was not associated with presence or progression of diabetic retinopathy; however, it was associated with higher risk of deterioration of visual acuity (multivariable-adjusted OR 1.83; 95% CI 1.34–2.48; P < 0.001). Conclusions Alcohol consumption is associated with increased risk of deterioration of visual acuity, but not with retinopathy in individuals with Type 2 diabetes.
- Subjects
DIABETIC retinopathy; CHI-squared test; COMPUTER software; CONFIDENCE intervals; ALCOHOL drinking; EPIDEMIOLOGY; LONGITUDINAL method; MEDICAL cooperation; TYPE 2 diabetes; RESEARCH; SELF-evaluation; VISUAL acuity; DATA analysis; MULTIPLE regression analysis; RELATIVE medical risk; SEVERITY of illness index; DISEASE risk factors
- Publication
Diabetic Medicine, 2010, Vol 27, Issue 10, p1130
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/j.1464-5491.2010.03080.x