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- Title
One‐hour post‐load glucose levels are associated with hepatic steatosis assessed by transient elastography.
- Authors
Andreozzi, Francesco; Mancuso, Elettra; Mazza, Elisa; Mannino, Gaia Chiara; Fiorentino, Teresa Vanessa; Arturi, Franco; Succurro, Elena; Perticone, Maria; Sciacqua, Angela; Montalcini, Tiziana; Pujia, Arturo; Sesti, Giorgio
- Abstract
Aim: To examine the association between 1‐hour plasma glucose (PG) concentration and markers of non‐alcoholic fatty liver disease (NAFLD) assessed by transient elastography (TE). Methods: We performed TE in 107 metabolically well‐characterized non‐diabetic White individuals. Controlled attenuation parameter (CAP) was used to quantify liver steatosis, while liver stiffness marker (LS) was used to evaluate fibrosis. Results: Controlled attenuation parameter correlated significantly with 1‐hour PG (r = 0.301, P < 0.01), fasting insulin (r = 0.285, P < 0.01), 2‐hour insulin (r = 0.257, P < 0.02), homeostasis model assessment index of insulin resistance (r = 0.252, P < 0.01), high‐density lipoprotein cholesterol (r = −0.252, P < 0.02), body mass index (BMI; r = 0.248, P < 0.02) and age (r = 0.212, P < 0.03), after correction for age, sex and BMI. In a multivariable linear regression analysis, 1‐hour PG (β = 0.274, P = 0.008) and fasting insulin levels (β = 0.225, P = 0.029) were found to be independent predictors of CAP. After excluding subjects with prediabetes, 1‐hour PG was the sole predictor of CAP variation (β = 0.442, P < 0.001). In a logistic regression model, we observed that the group with 1‐hour PG ≥ 8.6 mmol/L (155 mg/dL) had a significantly higher risk of steatosis (odds ratio 3.98, 95% confidence interval 1.43‐11.13; P = 0.008) than individuals with 1‐hour PG < 8.6 mmol/L, after correction for potential confounders. No association was observed between 1‐hour PG and LS. Conclusion: Our data confirm that 1‐hour PG ≥ 8.6 mmol/L is associated with higher signs of NAFLD, even among individuals with normal glucose tolerance, categorized as low risk by canonical diagnostic standards. TE is a safe low‐impact approach that could be employed for stratifying the risk profile in these patients, with a high level of accuracy.
- Subjects
FATTY liver; NON-alcoholic fatty liver disease; HDL cholesterol; INSULIN; BLOOD sugar; GLUCOSE
- Publication
Diabetes, Obesity & Metabolism, 2024, Vol 26, Issue 2, p682
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/dom.15358