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- Title
The influence of physical activity on vascular complications and mortality in patients with type 2 diabetes mellitus.
- Authors
Blomster, J. I.; Chow, C. K.; Zoungas, S.; Woodward, M.; Patel, A.; Poulter, N. R.; Marre, M.; Harrap, S.; Chalmers, J.; Hillis, G. S.
- Abstract
Aims There is limited evidence regarding the association between physical activity and vascular complications, particularly microvascular disease, in patients with type 2 diabetes. Methods From the 11 140 patients in the ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron modified release Controlled Evaluation) trial, the effect of physical activity, categorized as none, mild, moderate or vigorous, and the number of sessions within a week, was examined in multivariable regression models adjusted for potential confounders. The study end-points were major cardiovascular events, microvascular complications and all-cause mortality. Results Forty-six percent of participants reported undertaking moderate to vigorous physical activity for >15 min at least once in the previous week. During a median of 5 years of follow-up, 1031 patients died, 1147 experienced a major cardiovascular event and 1136 a microvascular event. Compared to patients who undertook no or mild physical activity, those reporting moderate to vigorous activity had a decreased risk of cardiovascular events ( HR: 0.78, 95% CI: 0.69-0.88, p < 0.0001), microvascular events ( HR: 0.85, 95% CI: 0.76-0.96, p = 0.010) and all-cause mortality ( HR: 0.83, 95% CI: 0.73-0.94, p = 0.0044). Conclusions Moderate to vigorous, but not mild, physical activity is associated with a reduced incidence of cardiovascular events, microvascular complications and all-cause mortality in patients with type 2 diabetes.
- Subjects
TYPE 2 diabetes complications; PHYSICAL activity; CARDIOVASCULAR diseases risk factors; REGRESSION analysis; RANDOMIZED controlled trials; CAUSES of death
- Publication
Diabetes, Obesity & Metabolism, 2013, Vol 15, Issue 11, p1008
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/dom.12122