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- Title
Relationship between the course of depression symptoms and the left ventricular mass index and left ventricular filling pressure in chronic haemodialysis patients.
- Authors
Yong Kyun Kim; Park, Chan S.; Sang-Hyun Ihm; Hee-Yeol Kim; Hong, Tai Y.; Kim, Dai J.; Pae, Chi-Un; Song, Ho C.; Yong-Soo Kim; Choi, Euy J.
- Abstract
Multiple measurements of depression symptoms over time were more predictive of cardiovascular mortality than a single time measurement performed at baseline. The aim of this study is to evaluate the association of the course of depression symptoms, based on repeated assessments of depression symptoms over time, with left ventricular mass index (LVMI) and left ventricular filling pressure (LVFP) in patients on haemodialysis (HD). The level of depression symptoms in 61 patients on HD were prospectively assessed using the Beck Depression Inventory (BDI) at baseline and at three intervals (5, 10, 15 months). Doppler echocardiographic examinations were performed at the end of follow up. At the end of follow up, the patients were divided into three groups according to their course of depression symptoms: non-depression ( n = 21), intermittent depression ( n = 23) and persistent depression ( n = 17). LVMI and LVFP were significantly increased in the persistent depression symptoms group compared to those of the non-depression symptoms group and the intermittent depression symptoms group. Persistent depression symptoms were independently associated with LVMI (β-coefficient = 0.347, P = 0.017) and LVFP (β-coefficient = 0.274, P = 0.048) after adjustment for age, sex, systolic blood pressure, diastolic blood pressure, diabetes and interdialytic weight gain. In our study, persistent depression symptoms were associated with left ventricular hypertrophy and diastolic dysfunction. Our data may provide a more complete understanding of cardiovascular risk associated with depression symptoms in patients on HD. Depression has previously been linked to left ventricular hypertrophy (LVH) in dialysis patients. This study demonstrates that only persistent depression correlates with LVH and diastolic dysfunction.
- Subjects
MENTAL depression risk factors; HEMODIALYSIS patients; CARDIAC hypertrophy; KIDNEY diseases; BECK Depression Inventory; PHYSIOLOGY; PATIENTS
- Publication
Nephrology, 2011, Vol 16, Issue 2, p180
- ISSN
1320-5358
- Publication type
Article
- DOI
10.1111/j.1440-1797.2010.01372.x