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- Title
Editorial Goodpasture's disease: Antiglomerular basement membrane disease.
- Authors
Erlich, Jonathan H.; Sevastos, Jacob; Pussell, Bruce A.
- Abstract
Goodpasture's disease, also known as antiglomerular basement membrane disease, is a rare but important cause of pulmonary haemorrhage (PH) and rapidly progressive crescentic glomerulonephritis (GN) that leads to irreversible renal failure. As an autoimmune disease, it is characterized by the production of pathogenic autoantibodies to the NC1 domain of the alpha 3 chain of type IV collagen which bind to basement membranes predominantly found in glomeruli and pulmonary tissue. Antiglomerular basement membrane disease usually presents with acute renal failure and PH. In the urine, there is the typical picture of a rapidly progressive GN with red and white cell casts and proteinuria.
- Subjects
PULMONARY artery; AUTOIMMUNE diseases; IMMUNOLOGIC diseases; ACUTE kidney failure; GLOMERULONEPHRITIS; IMMUNE complex diseases
- Publication
Nephrology, 2004, Vol 9, Issue 2, p49
- ISSN
1320-5358
- Publication type
Editorial
- DOI
10.1111/j.1440-1797.2004.00244.x