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- Title
Pharmacodynamics of peginterferon alfa-2a and peginterferon alfa-2b in interferon-naïve patients with chronic hepatitis C: a randomized, controlled study.
- Authors
BRUNO, R.; SACCHI, P.; SCAGNOLARI, C.; TORRIANI, F.; MAIOCCHI, L.; PATRUNO, S.; BELLOMI, F.; FILICE, G.; ANTONELLI, G.
- Abstract
Background Peginterferon alfa-2a and alfa-2b, the two commercially available pegylated interferons, have different pharmacokinetic properties that produce differing abilities to suppress replication of the hepatitis C virus. Aim To compare the pharmacodynamics of peginterferon alfa-2a and peginterferon alfa-2b in interferon-naive patients with chronic hepatitis C. Methods Patients were randomized to receive peginterferon alfa-2a, 180 μg ( n = 10) or peginterferon alfa-2b 1.0 μg/kg ( n = 12) once weekly. The enzymatic activity of 2′5′-oligoadenylate synthetase and levels of neopterin and β2-microglobulin were measured at baseline and at 24, 48, 120 and 168 h. Results Oligoadenylate synthetase activity and serum neopterin and β2-microglobulin concentrations did not differ significantly between the two patient groups at any time point, nor was there a significant correlation between the serum area under the concentration-time curve of either peginterferon and the area under the concentration-time curve for 2′,5′-oligoadenylate synthetase, neopterin and β2-microglobulin. The area under the concentration-time curves calculated for these three markers did not correlate with body mass index stratified at <25 and ≥25 kg/m2 for either peginterferon. Conclusions Despite pharmacokinetic differences between peginterferon alfa-2a and peginterferon alfa-2b, the pharmacodynamic profiles of the two formulations appear to be comparable.
- Subjects
PHARMACODYNAMICS; HEPATITIS C treatment; PATIENTS; OLIGOADENYLATES; PHARMACOKINETICS; VIRAL replication; DISEASES
- Publication
Alimentary Pharmacology & Therapeutics, 2007, Vol 26, Issue 3, p369
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/j.1365-2036.2007.03392.x