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- Title
Association of miR-146a gene polymorphism with risk of nasopharyngeal carcinoma in the central-southern Chinese population.
- Authors
Huang, Guo-Liang; Chen, Mei-Ling; Li, Ya-Zhen; Lu, Yan; Pu, Xing-Xiang; He, Yu-Xiang; Tang, Shu-Yin; Che, Hua; Zou, Ying; Ding, Congcong; He, Zhiwei
- Abstract
This case-control study focused on estimating the association between miR-146a polymorphism and risk of nasopharyngeal carcinoma (NPC) in central-south China. In total, 160 patients with NPC and 200 healthy controls in central-south China were genotyped using polymerase chain reaction-restriction fragment length polymorphism assay. Chi-square test was used to assess the different distribution of miR-146a polymorphism between NPC patients and controls; and logistic regression analysis was applied to analyze the associations between miR-146a polymorphism with cancer risk in different contrast models. Significant differences between NPC patients and controls were found in genotype (P=0.033 for GG versus CG versus CC; and odds ratio (OR)=0.568, 95% confidence interval (CI)=0.354-0.912, P=0.019 for CG versus CC; and OR=0.503, 95% CI=0.261-0.971, P=0.041 for CG versus CC; and OR=0.564, 95% CI=0.360-0.884, P=0.012 for GG+CG versus CC, respectively) and allelic analysis (P=0.025 for G versus C). Our findings suggested that polymorphism of mir-146a was associated with NPC in the central-southern Chinese population.
- Subjects
MICRORNA; GENETIC polymorphisms; CANCER risk factors; NASOPHARYNX cancer; CHINESE people; POLYMERASE chain reaction; RESTRICTION fragment length polymorphisms; DISEASES
- Publication
Journal of Human Genetics, 2014, Vol 59, Issue 3, p141
- ISSN
1434-5161
- Publication type
Article
- DOI
10.1038/jhg.2013.135