We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Anticoagulation in patients with acute kidney injury undergoing kidney replacement therapy.
- Authors
Raina, Rupesh; Chakraborty, Ronith; Davenport, Andrew; Brophy, Patrick; Sethi, Sidharth; McCulloch, Mignon; Bunchman, Timothy; Yap, Hui Kim
- Abstract
Kidney replacement therapy (KRT) is used to provide supportive therapy for critically ill patients with severe acute kidney injury and various other non-renal indications. Modalities of KRT include continuous KRT (CKRT), intermittent hemodialysis (HD), and sustained low efficiency daily dialysis (SLED). However, circuit clotting is a major complication that has been investigated extensively. Extracorporeal circuit clotting can cause reduction in solute clearances and can cause blood loss, leading to an upsurge in treatment costs and a rise in workload intensity. In this educational review, we discuss the pathophysiology of the clotting cascade within an extracorporeal circuit and the use of various types of anticoagulant methods in various pediatric KRT modalities.
- Subjects
THROMBOLYTIC therapy; THERAPEUTICS; THROMBOSIS; ARTIFICIAL blood circulation; ANTICOAGULANTS; RENAL replacement therapy; PEDIATRICS; PROSTACYCLIN; HEMODIALYSIS; HIRUDIN; ACUTE kidney failure
- Publication
Pediatric Nephrology, 2022, Vol 37, Issue 10, p2303
- ISSN
0931-041X
- Publication type
Article
- DOI
10.1007/s00467-021-05020-z