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- Title
An electronic, unsupervised patient-reported Expanded Disability Status Scale for multiple sclerosis.
- Authors
Romeo, Andrew R; Rowles, William M; Schleimer, Erica S; Barba, Patrick; Hsu, Wan-Yu; Gomez, Refujia; Santaniello, Adam; Zhao, Chao; Pearce, Jennifer R; Jones, JB; Cree, Bruce C; Hauser, Stephen L; Gelfand, Jeffrey M; Stewart, Walter F; Goodin, Douglas S; Bove, Riley M
- Abstract
Background: In persons with multiple sclerosis (MS), the Expanded Disability Status Scale (EDSS) is the criterion standard for assessing disability, but its in-person nature constrains patient participation in research and clinical assessments. Objective: The aim of this study was to develop and validate a scalable, electronic, unsupervised patient-reported EDSS (ePR-EDSS) that would capture MS-related disability across the spectrum of severity. Methods: We enrolled 136 adult MS patients, split into a preliminary testing Cohort 1 (n = 50), and a validation Cohort 2 (n = 86), which was evenly distributed across EDSS groups. Each patient completed an ePR-EDSS either immediately before or after a MS clinician's Neurostatus EDSS evaluation. Results: In Cohort 2, mean age was 50.6 years (range = 26–80) and median EDSS was 3.5 (interquartile range (IQR) = [1.5, 5.5]). The ePR-EDSS and EDSS agreed within 1-point for 86% of examinations; kappa for agreement within 1-point was 0.85 (p < 0.001). The correlation coefficient between the two measures was 0.91 (<0.001). Discussion: The ePR-EDSS was highly correlated with EDSS, with good agreement even at lower EDSS levels. For clinical care, the ePR-EDSS could enable the longitudinal monitoring of a patient's disability. For research, it provides a valid and rapid measure across the entire spectrum of disability and permits broader participation with fewer in-person assessments.
- Subjects
MULTIPLE sclerosis; MEDICAL research; PATIENT participation; MEDICAL personnel; DISABILITIES
- Publication
Multiple Sclerosis Journal, 2021, Vol 27, Issue 9, p1432
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458520968814