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- Title
Glucocerebrosidase mutations disrupt the lysosome and now the mitochondria.
- Authors
Klein, Andrés D.; Outeiro, Tiago Fleming
- Abstract
β-Glucocerebrosidase (GCase) mutations lead to glucosylceramide build-up in the lysosome, impacting α-synuclein aggregation and autophagy. Recently, Baden and colleagues found GCase in mitochondria, supporting mitochondrial complex I function and energy metabolism. We believe the newly described role of GCase in the mitochondria will inform new Parkinson's and Gaucher's disease therapeutics.
- Subjects
ENERGY metabolism; MITOCHONDRIA; PARKINSON'S disease; ALPHA-synuclein
- Publication
Nature Communications, 2023, Vol 14, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-023-42107-7