We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Cortical gyrification pattern of depression in Parkinson's disease: a neuroimaging marker for disease severity?
- Authors
Qin Shen; Haiyan Liao; Sainan Cai; Qinru Liu; Min Wang; Chendie Song; Fan Zhou; Yujing Liu; Jiaying Yuan; Yuqing Tang; Xu Li; Jun Liu; Changlian Tan
- Abstract
Background: Although the study of the neuroanatomical correlates of depression in Parkinson's Disease (PD) is gaining increasing interest, up to now the cortical gyrification pattern of PD-related depression has not been reported. This study was conducted to investigate the local gyrification index (LGI) in PD patients with depression, and its associations with the severity of depression. Methods: LGI values, as measured using FreeSurfer software, were compared between 59 depressed PD (dPD), 27 non-depressed PD (ndPD) patients and 43 healthy controls. The values were also compared between ndPD and milddepressed PD (mi-dPD), moderate-depressed PD (mo-dPD) and severe-depressed PD (se-dPD) patients as sub-group analyses. Furthermore, we evaluated the correlation between LGI values and depressive symptom scores within dPD group. Results: Compared to ndPD, the dPD patients exhibited decreased LGI in the left parietal, the right superior-frontal, posterior cingulate and paracentral regions, and the LGI values within these areas negatively correlated with the severity of depression. Specially, reduced gyrification was observed in mo-dPD and involving a larger region in se-dPD, but not in mi-dPD group. Conclusion: The present study demonstrated that cortical gyrification is decreased within specific brain regions among PD patients with versus without depression, and those changes were associated with the severity of depression. Our findings suggested that cortical gyrification might be a potential neuroimaging marker for the severity of depression in patients with PD.
- Subjects
STATISTICAL correlation; PEARSON correlation (Statistics); RESEARCH funding; KRUSKAL-Wallis Test; INTERVIEWING; PARKINSON'S disease; SEVERITY of illness index; DESCRIPTIVE statistics; CHI-squared test; MAGNETIC resonance imaging; CEREBRAL cortex; RESEARCH; ONE-way analysis of variance; RESEARCH methodology; BRAIN cortical thickness; COMPARATIVE studies; DATA analysis software; PSYCHOLOGICAL tests; MENTAL depression; DISEASE complications
- Publication
Frontiers in Aging Neuroscience, 2024, p1
- ISSN
1663-4365
- Publication type
Article
- DOI
10.3389/fnagi.2023.1241516