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- Title
The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas.
- Authors
Habr, Elias A. El; Adamopoulos, Christos; Levidou, Georgia; Saetta, Aggeliki A.; Korkolopoulou, Penelope; Piperi, Christina
- Abstract
Astrocytomas, the most common type of gliomas, and especially grade IV glioblastomas are "endowed" with strong proliferation and invasion potentials, high recurrence rate, and poor patients' prognosis. Aberrant signaling of AKT-mTOR (mammalian target of rapamycin) has been implicated in carcinogenesis. This paper is focused on the impact of deregulated AKT-mTOR signaling components in the clinical outcome and prognosis of human astrocytomas. Current therapeutic targeting of astrocytomas with AKT-mTOR inhibitors in preclinical and clinical stage is also discussed, including future perspectives regarding the management of these devastating tumors.
- Subjects
PROTEIN kinase B; ASTROCYTOMAS; RAPAMYCIN; GLIOMAS; GLIOBLASTOMA multiforme; CELL proliferation; HUMAN carcinogenesis; DISEASE relapse; PROGNOSIS
- Publication
Neurology Research International, 2012, p1
- ISSN
2090-1852
- Publication type
Article
- DOI
10.1155/2012/454957