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- Title
Gynostemma pentaphyllum Hydrodistillate and Its Major Component Damulin B Promote Hair Growth-Inducing Properties In Vivo and In Vitro via the Wnt/β-Catenin Pathway in Dermal Papilla Cells.
- Authors
Kovale, Lochana; Lee, Seoyeon; Song, Minhyeok; Lee, Jihyun; Son, Hyeong Jig; Sung, Young Kwan; Kwack, Mi Hee; Choe, Wonchae; Kang, Insug; Kim, Sung Soo; Ha, Joohun
- Abstract
Alopecia, a prevalent yet challenging condition with limited FDA-approved treatments which is accompanied by notable side effects, necessitates the exploration of natural alternatives. This study elucidated the hair growth properties of Gynostemma pentaphyllum leaf hydrodistillate (GPHD) both in vitro and in vivo. Furthermore, damulin B, a major component of GPHD, demonstrated hair growth-promoting properties in vitro. Beyond its established anti-diabetic, anti-obesity, and anti-inflammatory attributes, GPHD exhibited hair growth induction in mice parallel to minoxidil. Moreover, it upregulated the expression of autocrine factors associated with hair growth, including VEGF, IGF-1, KGF, and HGF. Biochemical assays revealed that minoxidil, GPHD, and damulin B induced hair growth via the Wnt/β-catenin pathway through AKT signaling, aligning with in vivo experiments demonstrating improved expression of growth factors. These findings suggest that GPHD and damulin B contribute to the hair growth-inducing properties of dermal papilla cells through the AKT/β-catenin signaling pathway.
- Subjects
DERMIS; BIOLOGICAL models; IN vitro studies; ANTI-inflammatory agents; MELONS; RESEARCH funding; HAIR follicles; CELL proliferation; MINOXIDIL; BALDNESS; CYTOSKELETAL proteins; CELLULAR signal transduction; IN vivo studies; DESCRIPTIVE statistics; PLANT extracts; MICE; ANIMAL experimentation; MOLECULAR structure; BIOLOGICAL assay; TRANSFERASES; SOMATOMEDIN; LEAVES; COMPARATIVE studies; WNT proteins; PHARMACODYNAMICS
- Publication
Nutrients, 2024, Vol 16, Issue 7, p985
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16070985