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- Title
3D Printing of Dietary Products for the Management of Inborn Errors of Intermediary Metabolism in Pediatric Populations.
- Authors
Carou-Senra, Paola; Rodríguez-Pombo, Lucía; Monteagudo-Vilavedra, Einés; Awad, Atheer; Alvarez-Lorenzo, Carmen; Basit, Abdul W.; Goyanes, Alvaro; Couce, María L.
- Abstract
The incidence of Inborn Error of Intermediary Metabolism (IEiM) diseases may be low, yet collectively, they impact approximately 6–10% of the global population, primarily affecting children. Precise treatment doses and strict adherence to prescribed diet and pharmacological treatment regimens are imperative to avert metabolic disturbances in patients. However, the existing dietary and pharmacological products suffer from poor palatability, posing challenges to patient adherence. Furthermore, frequent dose adjustments contingent on age and drug blood levels further complicate treatment. Semi-solid extrusion (SSE) 3D printing technology is currently under assessment as a pioneering method for crafting customized chewable dosage forms, surmounting the primary limitations prevalent in present therapies. This method offers a spectrum of advantages, including the flexibility to tailor patient-specific doses, excipients, and organoleptic properties. These elements are pivotal in ensuring the treatment's efficacy, safety, and adherence. This comprehensive review presents the current landscape of available dietary products, diagnostic methods, therapeutic monitoring, and the latest advancements in SSE technology. It highlights the rationale underpinning their adoption while addressing regulatory aspects imperative for their seamless integration into clinical practice.
- Subjects
INBORN errors of metabolism diagnosis; DIET in disease; BIOMARKERS; BIOSENSORS; ORAL drug administration; ARTIFICIAL intelligence; METABOLISM; WEARABLE technology; MEDICAL technology; DIETARY supplements; PHARMACEUTICAL arithmetic; DIET therapy; UNITED States. Food &; Drug Administration; DRUG monitoring; GENE therapy; QUALITY of life; QUALITY control; THREE-dimensional printing; INBORN errors of metabolism; PHARMACEUTICAL chemistry; LIVER transplantation; EARLY diagnosis
- Publication
Nutrients, 2024, Vol 16, Issue 1, p61
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16010061