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- Title
Biochemical and Metabolical Pathways Associated with Microbiota-Derived Butyrate in Colorectal Cancer and Omega-3 Fatty Acids Implications: A Narrative Review.
- Authors
Gheorghe, Adelina Silvana; Negru, Șerban Mircea; Preda, Mădălina; Mihăilă, Raluca Ioana; Komporaly, Isabela Anda; Dumitrescu, Elena Adriana; Lungulescu, Cristian Virgil; Kajanto, Lidia Anca; Georgescu, Bogdan; Radu, Emanuel Alin; Stănculeanu, Dana Lucia
- Abstract
Knowledge regarding the influence of the microbial community in cancer promotion or protection has expanded even more through the study of bacterial metabolic products and how they can modulate cancer risk, which represents an extremely challenging approach for the relationship between intestinal microbiota and colorectal cancer (CRC). This review discusses research progress on the effect of bacterial dysbiosis from a metabolic point of view, particularly on the biochemical mechanisms of butyrate, one of the main short chain fatty acids (SCFAs) with anti-inflammatory and anti-tumor properties in CRC. Increased daily intake of omega-3 polyunsaturated fatty acids (PUFAs) significantly increases the density of bacteria that are known to produce butyrate. Omega-3 PUFAs have been proposed as a treatment to prevent gut microbiota dysregulation and lower the risk or progression of CRC.
- Subjects
THERAPEUTIC use of antineoplastic agents; BIOMARKERS; LIFESTYLES; DNA; GUT microbiome; ANTI-inflammatory agents; COLORECTAL cancer; CELLULAR signal transduction; GENE expression; OMEGA-3 fatty acids; BUTYRIC acid; LONGITUDINAL method
- Publication
Nutrients, 2022, Vol 14, Issue 6, p1152
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14061152