We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Colostrum Therapy for Human Gastrointestinal Health and Disease.
- Authors
Chandwe, Kanta; Kelly, Paul
- Abstract
There is increasing awareness that a broad range of gastrointestinal diseases, and some systemic diseases, are characterized by failure of the mucosal barrier. Bovine colostrum is a complex biological fluid replete with growth factors, nutrients, hormones, and paracrine factors which have a range of properties likely to contribute to mucosal healing in a wide range of infective, inflammatory, and injury conditions. In this review, we describe the anatomy and physiology of the intestinal barrier and how it may fail. We survey selected diseases in which disordered barrier function contributes to disease pathogenesis or progression, and review the evidence for or against efficacy of bovine colostrum in management. These disorders include enteropathy due to non-steroidal anti-inflammatory drugs (NSAIDs), inflammatory bowel disease (IBD), necrotizing enterocolitis, infectious diarrhea, intestinal failure, and damage due to cancer therapy. In animal models, bovine colostrum benefits NSAID enteropathy, IBD, and intestinal failure. In human trials, there is substantial evidence of efficacy of bovine colostrum in inflammatory bowel disease and in infectious diarrhea. Given the robust scientific rationale for using bovine colostrum as a promoter of mucosal healing, further work is needed to define its role in therapy.
- Subjects
INTESTINAL disease treatment; GASTROINTESTINAL disease treatment; INFLAMMATORY bowel disease treatment; DISEASE progression; NEONATAL necrotizing enterocolitis; WOUND healing; CATTLE; DIARRHEA; NONSTEROIDAL anti-inflammatory agents; GASTROINTESTINAL diseases; COLOSTRUM; DIETARY supplements; TREATMENT effectiveness; INTESTINAL mucosa; EVALUATION
- Publication
Nutrients, 2021, Vol 13, Issue 6, p1956
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13061956