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- Title
Probiotic and Functional Properties of Limosilactobacillus reuteri INIA P572.
- Authors
Diez-Echave, Patricia; Martín-Cabrejas, Izaskun; Garrido-Mesa, José; Langa, Susana; Vezza, Teresa; Landete, José M.; Hidalgo-García, Laura; Algieri, Francesca; Mayer, Melinda J.; Narbad, Arjan; García-Lafuente, Ana; Medina, Margarita; Rodríguez-Nogales, Alba; Rodríguez-Cabezas, María Elena; Gálvez, Julio; Arqués, Juan L.
- Abstract
Limosilactobacillus reuteri INIA P572 is a strain able to produce the antimicrobial compound reuterin in dairy products, exhibiting a protective effect against some food-borne pathogens. In this study, we investigated some probiotic properties of this strain such as resistance to gastrointestinal passage or to colonic conditions, reuterin production in a colonic environment, and immunomodulatory activity, using different in vitro and in vivo models. The results showed a high resistance of this strain to gastrointestinal conditions, as well as capacity to grow and produce reuterin in a human colonic model. Although the in vitro assays using the RAW 264.7 macrophage cell line did not demonstrate direct immunomodulatory properties, the in vivo assays using a Dextran Sulphate Sodium (DSS)-induced colitic mice model showed clear immunomodulatory and protective effects of this strain.
- Subjects
GUT microbiome; IN vitro studies; IN vivo studies; ANIMAL experimentation; BACTERIOLOGY technique; MACROPHAGES; ANTI-infective agents; DAIRY products; PROBIOTICS; IMMUNOLOGICAL adjuvants; LACTOBACILLUS; CELL lines; MICE
- Publication
Nutrients, 2021, Vol 13, Issue 6, p1860
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13061860