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- Title
The Microbiome as a Therapy in Pouchitis and Ulcerative Colitis.
- Authors
LeBlanc, Jean-Frédéric; Segal, Jonathan P.; de Campos Braz, Lucia Maria; Hart, Ailsa L.
- Abstract
The gut microbiome has been implicated in a range of diseases and there is a rapidly growing understanding of this ecosystem's importance in inflammatory bowel disease. We are yet to identify a single microbe that causes either ulcerative colitis (UC) or pouchitis, however, reduced microbiome diversity is increasingly recognised in active UC. Manipulating the gut microbiome through dietary interventions, prebiotic and probiotic compounds and faecal microbiota transplantation may expand the therapeutic landscape in UC. Specific diets, such as the Mediterranean diet or diet rich in omega-3 fatty acids, may reduce intestinal inflammation or potentially reduce the risk of incident UC. This review summarises our knowledge of gut microbiome therapies in UC and pouchitis.
- Subjects
ULCERATIVE colitis; MEDITERRANEAN diet; PREBIOTICS; GUT microbiome; INFLAMMATION; ILEITIS; PROBIOTICS; TREATMENT effectiveness; OMEGA-3 fatty acids; FECAL microbiota transplantation
- Publication
Nutrients, 2021, Vol 13, Issue 6, p1780
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13061780