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- Title
Preventive electroacupuncture ameliorates D-galactose-induced Alzheimer's disease-like inflammation and memory deficits, probably via modulating the microbiota-gut-brain axis.
- Authors
Chuan He; Zhong-Sheng Huang; Chao-Chao Yu; Xue-Song Wang; Tao Jiang; Miao Wu; Li-Hong Kong
- Abstract
Indeed, both the intestinal barrier and the BBB are weakened during aging, and the malfunction of these physiological barriers may lead to systemic inflammation and chronic neuro-inflammation, which is thought to contribute to the pathogenesis of AD (56). Notably, TLR4/NF-kB signaling can be significantly inhibited by EA intervention in aging rats and a previous study also indicating that EA treatment at ST36 can inhibit TLR4/NF- B signaling thus alleviating LPS-induced inflammation in rats (62). Preventive electroacupuncture ameliorates D-galactose-induced Alzheimer's diseaselike inflammation and memory deficits, probably via modulating the microbiota-gut-brain axis.
- Subjects
GALACTOSE; MEDICAL sciences; ELECTROACUPUNCTURE; MYOSIN light chain kinase; MAZE tests
- Publication
Iranian Journal of Basic Medical Sciences, 2021, Vol 24, Issue 3, p341
- ISSN
2008-3866
- Publication type
Article
- DOI
10.22038/ijbms.2021.49147.11256