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- Title
Relationship of Paraoxonase 1 (PON1) Gene Polymorphisms and Functional Activity With Systemic Oxidative Stress and Cardiovascular Risk.
- Authors
Bhattacharyya, Tamali; Nicholls, Stephen J.; Topol, Eric J.; Renliang Zhang; Xia Yang; Schmitt, David; Xiaoming Fu; Mingyuan Shao; Brennan, Danielle M.; Ellis, Stephen G.; Brennan, Marie-Luise; Allayee, Hooman; Lusis, Aldons J.; Hanzen, Stanley L.
- Abstract
The article reports on research which investigated the relationship of genetic and biochemical determinants of Paraoxonase 1 activity with systematic measures of oxidative stress and cardiovascular disease risk in humans. Researchers examined 1,399 consenting patients undergoing diagnostic coronary angiography between September 2002 and November 2003. Researchers found that the Paraoxonase genotype demonstrated significant dose related associations with decreased levels of serum Paraoxanase 1 activity and with increased levels of systemic indices of oxidative stress and that patients with the QQ192 genotype demonstrated an increased risk of all cause mortality.
- Subjects
GENETIC research; GENETIC polymorphisms; OXIDATIVE stress; CARDIOVASCULAR diseases; MEDICAL genetics; PARAOXONASE
- Publication
JAMA: Journal of the American Medical Association, 2008, Vol 299, Issue 11, p1265
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.299.11.1265