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- Title
Effects of Citalopram and Interpersonal Psychotherapy on Depression in Patients With Coronary Artery Disease.
- Authors
Lespérance, François; Frasure-Smith, Nancy; Koszycki, Diana; Laliberté, Marc-André; van Zyl, Louis T.; Baker, Brian; Swenson, John Robert; Ghatavi, Kayhan; Abramson, Beth L.; Dorian, Paul; Guertin, Marie-Claude
- Abstract
This article reports on results from the Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy, a blinded controlled trial testing the efficacy of selective serotonin reuptake inhibitors (SSRIs) on patients with coronary heart disease. Between 17% and 27% of patients with artery disease also suffer from depression and it can inhibit recovery. This trial documents the effects of citalopram in conjuction with psychotherapy in reducing depression among patients. The results strongly suggested the safety of using SSRIs on heart disease patients but a larger trial is needed to determine if its use can lower cardiac events.
- Subjects
PSYCHOLOGY; HEART diseases; THERAPEUTICS; MENTAL depression; SEROTONIN uptake inhibitors; SEROTONIN; INTERPERSONAL psychotherapy; CLINICAL trials
- Publication
JAMA: Journal of the American Medical Association, 2007, Vol 297, Issue 4, p367
- ISSN
0098-7484
- Publication type
Article