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- Title
Sustained physical activity in peripheral artery disease: Associations with disease severity, functional performance, health-related quality of life, and subsequent serious adverse events in the LITE randomized clinical trial.
- Authors
Slysz, Joshua T; Rejeski, W. Jack; Treat-Jacobson, Diane; Bazzano, Lydia A; Forman, Daniel E; Manini, Todd M; Criqui, Michael H; Tian, Lu; Zhao, Lihui; Zhang, Dongxue; Guralnik, Jack M; Ferrucci, Luigi; Kibbe, Melina R; Polonsky, Tamar S; Spring, Bonnie; Sufit, Robert; Leeuwenburgh, Christiaan; McDermott, Mary M
- Abstract
This study investigated cross-sectional associations of peripheral artery disease (PAD) severity (defined by the ankle–brachial index (ABI)) and amounts of daily sustained physical activity (PA) (defined as > 100 activity counts per minute lasting 5 consecutive minutes or more). This study also investigated associations of amounts of daily sustained PA with 6-minute walk (6MW) distance and the Short Form-36 physical functioning domain (SF-36 PF) score in cross-sectional analyses and with serious adverse events (SAEs) in longitudinal analyses of people with PAD. PA was measured continuously for 10 days using a tri-axial accelerometer at baseline in 277 participants with PAD randomized to the LITE clinical trial. In regression analyses, each 0.15 lower ABI value was associated with a 5.67% decrease in the number of daily bouts of sustained PA (95% CI: 3.85–6.54; p < 0.001). Every additional bout of sustained PA per day was associated with a 4.56-meter greater 6MW distance (95% CI: 2.67–6.46; p < 0.0001), and a 0.81-point improvement in SF-36 PF score (95% CI: 0.34–1.28; p < 0.001). Participants with values of daily bouts of sustained PA below the median had higher rates of SAEs during follow-up, compared to participants above the median (41% vs 24%; p = 0.002). In conclusion, among participants with PAD, lower ABI values were associated with fewer bouts of daily sustained PA. A greater number of bouts of daily sustained PA were associated with better 6MW performance and SF-36 PF score, and, in longitudinal analyses, lower rates of SAEs. Clinicaltrials.gov ID: NCT02538900.
- Subjects
PERIPHERAL vascular diseases; FUNCTIONAL status; PHYSICAL activity; QUALITY of life; CLINICAL trials
- Publication
Vascular Medicine, 2021, Vol 26, Issue 5, p497
- ISSN
1358-863X
- Publication type
Article
- DOI
10.1177/1358863X21989430