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- Title
Ameliorative effect of quercetin on the destruction caused by experimental periodontitis in rats Cheng et al. Quercetin on periodontal destruction of rat.
- Authors
Cheng, W.‐C.; Huang, R.‐Y.; Chiang, C.‐Y.; Chen, J.‐K.; Liu, C.‐H.; Chu, C.‐L.; Fu, E.
- Abstract
Cheng W-C, Huang R-Y, Chiang C-Y, Chen J-K, Liu C-H, Chu C-L, Fu E. Ameliorative effect of quercetin on the destruction caused by experimental periodontitis in rats. J Periodont Res 2010; 45: 788-795. © 2010 John Wiley & Sons A/S The purpose of this study was to evaluate the effect of quercetin, a flavonol that exhibits anti-inflammatory properties, on experimental periodontal destruction in rats. Osteoclast formation on maxillary palatal alveolus was induced with daily lipopolysaccharide (LPS) injections (0, 1 or 5 mg/mL) for 3 d. Five days later, the osteoclasts on bony surfaces were counted after histochemical staining for tartrate-resistant acid phosphatase. The effect of intragastric quercetin on the osteoclast formation was evaluated in the following three groups: quercetin (75 mg/kg/d by oral feeding); LPS (5 mg/mL); and quercetin plus LPS. Moreover, the effect of quercetin on the ligature-induced periodontitis around maxillary second and mandibular first molars was further evaluated by microcomputerized tomography (on days 0, 4, 8 and 12) and by histometry (on day 8). A dose-dependent increase in osteoclasts occurred after LPS injections. However, quercetin (75 mg/kg) reduced the 5 mg/mL LPS-induced osteoclasts. Using microcomputerized tomography, the bone crest levels at ligation sites were found to be significantly more apical than at the control sites on days 8 and 12; however, the apically located bone crests rebounded in rats from the quercetin-plus-ligation group. Histometry demonstrated significantly more coronal alveolar crest bone levels, less inflammatory cell-infiltrated connective tissue areas and less connective tissue attachments in the ligation-plus-quercetin group compared with those in the ligation group. As the quercetin could reduce the LPS-induced osteoclast formation and the ligature-enhanced periodontal inflammation and bone loss, we suggest that it may have an ameliorative effect on periodontal destruction.
- Subjects
ANTI-inflammatory agents; ANALYSIS of variance; ANIMAL experimentation; DOSE-effect relationship in pharmacology; HISTOLOGICAL techniques; PERIODONTAL disease; QUERCETIN; RATS; STATISTICAL significance; REPEATED measures design; DRUG therapy
- Publication
Journal of Periodontal Research, 2010, Vol 45, Issue 6, p788
- ISSN
0022-3484
- Publication type
Article
- DOI
10.1111/j.1600-0765.2010.01301.x