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- Title
The expressions of claudin-1 and E-cadherin in junctional epithelium.
- Authors
Fujita, T.; Hayashida, K.; Shiba, H.; Kishimoto, A.; Matsuda, S.; Takeda, K.; Kawaguchi, H.; Kurihara, H.
- Abstract
Fujita T, Hayashida K, Shiba H, Kishimoto A, Matsuda S, Takeda K, Kawaguchi H, Kurihara H. The expressions of claudin-1 and E-cadherin in junctional epithelium. J Periodont Res 2010; 45: 579–582. © 2010 John Wiley & Sons A/S Background and Objective: The epithelium provides an important barrier against microbial invasion. Tight junction structural proteins called claudins are known to contribute to the epithelial cell barrier. Junctional epithelium is located at a strategically important interface between gingival sulcus and is interconnected by desmosomes and gap junctions, but not by tight junctions. Although claudins are tight junction-associated proteins, they are also expressed in the epithelium despite its lack of tight junctions in invertebrates. Therefore, claudins may play an important role in junctional epithelium without tight junctions. E-cadherin is a key molecule in the formation of adherence junctions and desmosomes. In the present study, we aimed to investigate the expressions of claudin-1,claudin-3, claudin-7 and E-cadherin in the junctional epithelium of Fischer 344 rats. Material and Methods: Gingival tissues from Fischer 344 rats were analyzed by immunohistochemical staining for claudin-1, claudin-3, claudin-7, and E-cadherin. Results: Intense staining for claudin-1 and E-cadherin were observed in the junctional epithelium. In contrast to claudin-1, claudin-3 was mainly expressed in oral gingival epithelium and claudin-7 could not be detected on immunohistochemical analysis of the rat gingiva. Conclusion: These data suggest that claudin-1 and E-cadherin exist in the junctional epithelium and may play an important role in epithelial barrier function.
- Subjects
CADHERINS; CELL adhesion molecules; TIGHT junctions; EPITHELIAL cells; BIOMOLECULES
- Publication
Journal of Periodontal Research, 2010, Vol 45, Issue 4, p579
- ISSN
0022-3484
- Publication type
Article
- DOI
10.1111/j.1600-0765.2009.01258.x