We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Gene Expression of the Central and Peripheral Nervous System Myelin Membrane 2', 3'-Cyclic Nucleotide 3'-Phosphodiesterase in Development.
- Authors
Edwards, Aled M.; Braun, Peter E.
- Abstract
Determination of gene expression for the 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNP) during development shows that the amount of translatable RNA encoding this enzyme increases in parallel with myelination in the mouse brain. The two isoforms of this enzyme are developmentally regulated in parallel, in contrast to several other myelin proteins. By comparison, the amount of translatable RNA encoding CNP in the peripheral nervous system (rat sciatic nerve) remains constant during development. The two isoforms that are expressed are identical in apparent molecular weight to rat brain CNP. Moreover, no apparent differences were detected by proteolytic digestion (Cleveland mapping) of CNP 1 from the central or peripheral nervous systems. Copyright © 1988 S. Karger AG, Basel
- Publication
Developmental Neuroscience, 1988, Vol 10, Issue 2, p75
- ISSN
0378-5866
- Publication type
Article
- DOI
10.1159/000111958