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- Title
Lessons of the month 1: Polytrauma in a geriatric patient resulting in reactivation of cytomegalovirus infection and secondary cold agglutinin disease-induced haemolytic anaemia.
- Authors
Stockdale, Thomas; Hosack, Tom; Griffiths, Cameron; Mandal, Amit K. J.; Missouris, Constantinos G.
- Abstract
Haemolysis is a rare but serious complication of cytomegalovirus (CMV) infection, described mostly in immunocompromised patients, the pathogenesis of which is yet to be fully elucidated. We describe a case of Coombs-positive haemolytic anaemia in an older Caucasian immunocompetent woman after polytrauma, resulting from suspected reactivation of CMV infection and secondary cold agglutinin disease. Clinicians should consider CMV infection in the differential diagnosis of haemolytic anaemia in immunocompetent older adults who are admitted with significant musculoskeletal trauma. Early treatment with B-cell depletion therapy to halt cold agglutinin production can be life-saving.
- Subjects
INJURY complications; DISEASE relapse; B cells; COOMBS' test; CYTOMEGALOVIRUS diseases; DIFFERENTIAL diagnosis; AUTOIMMUNE hemolytic anemia; RARE diseases; IMMUNOCOMPROMISED patients; MIXED infections; DISEASE risk factors; OLD age
- Publication
Clinical Medicine, 2020, Vol 20, Issue 4, p433
- ISSN
1470-2118
- Publication type
Article
- DOI
10.7861/clinmed.2020-0176