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- Title
A critical body residue approach for predicting persistent bioaccumulative toxicant effects on reproduction and population dynamics of meiobenthic copepods.
- Authors
Chandler, G. Thomas; Ferguson, P. Lee; Klauber, W.W.; Washburn, K.M.
- Abstract
Critical body residues (CBRs) are the measured tissue toxicant concentrations yielding a median dose-response on a dry-weight or lipid-normalized basis. They facilitate management decisions for species protection using tissue analysis. Population CBR is the mean dose yielding 50% population suppression and was predicted here in Amphiascus tenuiremis for fipronil sulfide (FS) using lifetables and the Leslie matrix. Microplate bioassays (ASTM E-2317-14) produced biomass sufficient for dry mass and lipid-normalized CBR estimates of reproduction (fertility) and population growth suppression. Significant FS toxic effects were delayed naupliar development (at ≥0.10 µg L−1), delayed copepodite development (at 0.85 µg L−1), decreased reproductive success (at ≥ 0.39 µg L−1), and decreased offspring production (at 0.85 µg L−1). A reproductive median effective concentration (EC50) of 0.16 µg L−1 (95% CI: 0.12-0.21 µg L−1) corresponded to an adult all-sex CBR and lipid-normalized CBR of 0.38 pg FS · µg−1 dry weight (95% CI: 0.27-0.52 pg FS · µg−1) or 2.8 pg FS · µg−1 lipid (95% CI: 2.2-3.6 pg FS · µg−1), respectively. Copepod log bioconcentration factor (BCF) = 4.11 ± 0.2. Leslie matrix projections regressed against internal dose predicted fewer than five gravid females in a population by the third generation at 0.39 and 0.85 µg FS · L−1 (i.e., 9.6-10.2 µg FS · µg−1 lipid), and 50% population suppression at a CBR of 1.6 pg FS · µg−1 lipid. This more integrative population CBR as a management tool would fall 1.75 times below the CBR for the single most sensitive endpoint-fertility rate. Environ. Toxicol. Chem. 2012; 31: 1076-1082. © 2012 SETAC
- Subjects
AGRICULTURAL chemicals; POPULATION dynamics; TOXICOLOGY of water pollution; ESTUARINE ecology; MICROPLATES; BIOMASS
- Publication
Environmental Toxicology & Chemistry, 2012, Vol 31, Issue 5, p1076
- ISSN
0730-7268
- Publication type
Article
- DOI
10.1002/etc.1766