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- Title
Three-Component C1 Alkynylation of Tetrahydroisoquinolines Catalyzed by Silver Acetate.
- Authors
Shao, Guang; He, Yanjian; Xu, Ying; Chen, Jian; Yu, Huijuan; Cao, Rihui
- Abstract
A highly efficient method to fulfil the three-component C1 alkynylation of tetrahydroisoquinolines catalyzed by silver acetate was developed. This method features excellent regioselectivity and mild reaction conditions, is oxidant free, and can be performed in air. The power of this methodology was demonstrated by the rapid construction of the core structure of the natural product (tetrahydroberberine).
- Subjects
TETRAHYDROISOQUINOLINES; SILVER acetate; CATALYSIS research; REGIOSELECTIVITY (Chemistry); HETEROCYCLIC compounds
- Publication
European Journal of Organic Chemistry, 2015, Vol 2015, Issue 21, p4615
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201500526