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- Title
Microwave-Assisted Synthesis of Substituted Pyrrolo[2,3- d]pyrimidines.
- Authors
Prieur, Vanessa; Rubio‐Martínez, Jaime; Font‐Bardia, Mercè; Guillaumet, Gérald; Pujol, M. Dolors
- Abstract
A new synthetic route to triaryl pyrrolo[2,3- d]pyrimidines from common 4,6-dichloropyrimidine has been developed. The triarylated compounds are synthesized by three cross-coupling reactions using three different catalysts. The introduction of a C-6 aryl group was achieved in a two-step process under Sonogashira conditions [Pd(dba)2/CuI] followed by intramolecular cyclization, and application of Suzuki-Miyaura conditions [Pd(PPh3)4; PdCl2(PPh3)2] led to C-4 and C-5 diarylation. This sequence allows a flexible synthetic approach to highly arylated pyrrolopyrimidines containing different aryl groups.
- Subjects
NITROGEN; MICROWAVE chemistry; ARYL group; HETEROCYCLIC compounds; NUCLEOSIDES
- Publication
European Journal of Organic Chemistry, 2014, Vol 2014, Issue 7, p1514
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201301496