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- Title
One-Pot Transformation of Carboxylic Acids into Nitriles.
- Authors
Miyagi, Kotaro; Moriyama, Katsuhiko; Togo, Hideo
- Abstract
A variety of aromatic and aliphatic carboxylic acids were smoothly converted into the corresponding nitriles in good yields in a one-pot procedure by treatment with ethyl iodide/K2CO3/18-crown-6, followed by sodium diisobutyl- tert-butoxyaluminium hydride (SDBBA-H), and finally treatment with molecular iodine or 1,3-diiodo-5,5-dimethylhydantoin (DIH), and aqueous ammonia. This method is useful for the conversion of various aromatic and aliphatic carboxylic acids into the corresponding nitriles in a one-pot procedure.
- Subjects
CARBOXYLIC acids; NITRILES; SODIUM hydride; IODINE; AMMONIA; AROMATIC compounds
- Publication
European Journal of Organic Chemistry, 2013, Vol 2013, Issue 26, p5886
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201300629