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- Title
Global Respiratory Syncytial Virus–Related Infant Community Deaths.
- Authors
Mazur, Natalie I; Löwensteyn, Yvette N; Willemsen, Joukje E; Gill, Christopher J; Forman, Leah; Mwananyanda, Lawrence M; Blau, Dianna M; Breiman, Robert F; Madhi, Shabir A; Mahtab, Sana; Gurley, Emily S; Arifeen, Shams El; Assefa, Nega; Scott, J Anthony G; Onyango, Dickens; Barr, Beth A Tippet; Kotloff, Karen L; Sow, Samba O; Mandomando, Inacio; Ogbuanu, Ikechukwu
- Abstract
Background Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized. Methods The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital. Results We studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8−3.3) was lower than in-hospital (2.4 months; IQR: 1.5−4.0; P < .0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P < 0.0001). Conclusions We observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in-hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines.
- Subjects
MIDDLE-income countries; HEALTH risk assessment; AGE distribution; WORLD health; COMMUNITY health services; POPULATION geography; COMPARATIVE studies; HOSPITAL mortality; LOW-income countries; INDEPENDENT living; DESCRIPTIVE statistics; RESPIRATORY syncytial virus infections; CHILDREN
- Publication
Clinical Infectious Diseases, 2021, Vol 73, pS229
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciab528