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- Title
Durability and Long-term Clinical Outcomes of Fecal Microbiota Transplant Treatment in Patients With Recurrent Clostridium difficile Infection.
- Authors
Mamo, Yafet; Woodworth, Michael H; Wang, Tiffany; Dhere, Tanvi; Kraft, Colleen S
- Abstract
Background. Fecal microbiota transplant (FMT) appears safe and effective for treatment of recurrent Clostridium difficile infection (RCDI). However, durability, long-term clinical outcomes, and patient satisfaction after FMT are not well described. Methods. Eligible patients who received FMT for RCDI at Emory Hospital between 1 July 2012 and 31 December 2016 were contacted via telephone for a follow-up survey. Of 190 eligible patients, 137 (72%) completed the survey. Results. Median time from last FMT to follow-up was 22 months. Overall, 82% (113/137) of patients at follow-up had no recurrence of C. difficile infection (CDI) post-FMT (non-RCDI group) and 18% (24/137) of patients had CDI post-FMT (RCDI group). Antibiotic exposure for non-CDI infections after FMT was more common in the RCDI group compared to the non-RCDI group (75% vs 38%, P = .0009). Overall, 11% of patients reported improvement or resolution of diagnoses not related to CDI post-FMT, and 33% reported development of a new medical condition or symptom post-FMT. Ninety-five percent of patients (122/128) indicated that they would undergo FMT again, and 70% of these 122 reported that they would prefer FMT to antibiotics as initial treatment if they were to have a CDI recurrence. Conclusions. In this follow-up survey of outcomes after FMT at a median of 22 months follow-up, 82% of patients had durable cure of CDI. Patients with recurrence had more post-FMT antibiotic exposure, underscoring the need for thoughtful antibiotic use and a potential role for prophylactic microbiome enrichment to reduce recurrence.
- Subjects
BACTERIAL disease treatment; ANTIBIOTICS; DIAGNOSIS of bacterial diseases; BACTERIAL diseases; CLOSTRIDIOIDES difficile; HEALTH facilities; PATIENT aftercare; PATIENT satisfaction; SURVEYS; TIME; DISEASE relapse; TREATMENT effectiveness; SYMPTOMS
- Publication
Clinical Infectious Diseases, 2018, Vol 66, Issue 11, p1705
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/cix1097