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- Title
Sterically Controlled Alkylation of Arenes through Iridium-Catalyzed CH Borylation.
- Authors
Robbins, Daniel W.; Hartwig, John F.
- Abstract
Complementary chemistry: A one‐pot method for the site‐selective alkylation of arenes controlled by steric effects is reported. The process occurs through Ir‐catalyzed CH borylation, followed by Pd‐ or Ni‐catalyzed coupling with alkyl electrophiles. This selectivity complements that of the typical Friedel–Crafts alkylation; meta‐selective alkylation of a broad range of arenes with various electronic properties and functional groups occurs in good yield with high site selectivity.
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 3, p933
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201208203