We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Serum levels of ADAM12-S: possible association with the initiation and progression of dermal fibrosis and interstitial lung disease in patients with systemic sclerosis.
- Authors
Taniguchi, T.; Asano, Y.; Akamata, K.; Aozasa, N.; Noda, S.; Takahashi, T.; Ichimura, Y.; Toyama, T.; Sumida, H.; Kuwano, Y.; Yanaba, K.; Tada, Y.; Sugaya, M.; Kadono, T.; Sato, S.
- Abstract
Background A disintegrin and metalloprotease (ADAM) 12 is one of the metalloproteinase-type ADAMs and possesses extracellular metalloprotease and cell-binding functions. ADAM12 is expressed in two alternative forms, such as a membrane-anchored form (ADAM12-L) and a short secreted form (ADAM12-S). Objective To investigate the clinical significance of serum ADAM12-S levels in systemic sclerosis (SSc). Methods Serum ADAM12-S levels were determined by a specific enzyme-linked immunosorbent assay in 61 SSc patients and 18 healthy controls. Results Serum ADAM12-S levels were significantly increased in diffuse cutaneous SSc (dcSSc) patients than in healthy controls (0.417 ± 0.389 vs. 0.226 ± 0.065 ng/mL; P < 0.05), while being comparable between limited cutaneous SSc (0.282 ± 0.258 ng/mL) and healthy controls. Serum ADAM12-S levels significantly elevated in dcSSc patients with disease duration of ≤6 years (0.537 ± 0.449 ng/mL, P < 0.05), but not in dcSSc with disease duration of >6 years (0.225 ± 0.049 ng/mL), compared to healthy controls. Furthermore, in dcSSc patients with disease duration of ≤6 years, serum ADAM12-S levels correlated positively with modified Rodnan total skin thickness score, ground glass score, and serum C-reactive protein values, while showed inverse correlation with fibrosis score. Conclusion Elevated serum ADAM12-S levels are associated with elevated serum inflammatory marker, severity of skin fibrosis, and activity of interstitial lung disease in dcSSc, suggesting the possible contribution of ADAM12-S to the pathological events in this disorder.
- Subjects
SERUM; FIBROSIS; SKIN diseases; SYSTEMIC scleroderma; DISINTEGRINS; METALLOPROTEINASES; ENZYME-linked immunosorbent assay; PATIENTS
- Publication
Journal of the European Academy of Dermatology & Venereology, 2013, Vol 27, Issue 6, p747
- ISSN
0926-9959
- Publication type
Article
- DOI
10.1111/j.1468-3083.2012.04558.x