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- Title
Synergistic antitumor efficacy of antibacterial helvolic acid from Cordyceps taii and cyclophosphamide in a tumor mouse model.
- Authors
Jian-Hui Xiao; Yao Zhang; Gui-You Liang; Ru-Ming Liu; Xiao-Gang Li; Ling-Tao Zhang; Dai-Xiong Chen; Jian-Jiang Zhong
- Abstract
The antibacterial agent helvolic acid, which was isolated from the active antitumor fraction of Cordyceps taii, showed potent cytotoxicity against different human cancer cells. In the present study, the in vivo antitumor effect of helvolic acid was investigated in murine sarcoma S180 tumor-bearing mice. Doses of 10 and 20mg/kg/day helvolic acid did not exert significant antitumor activity. Interestingly, co-administration of 10mg/kg/day helvolic acid and 20mg/kg/day cyclophosphamide (CTX) - a well-known chemotherapy drug - showed promising antitumor activity with a growth inhibitory rate of 70.90%, which was much higher than that of CTX alone (19.5%). Furthermore, the combination markedly prolonged the survival of tumor-bearing mice. In addition, helvolic acid enhanced the immune organ index. The protein expression levels of β-catenin, cyclin D1, and proliferating cell nuclear antigen were significantly suppressed in mice treated with 20mg/kg/day helvolic acid and in those receiving combination therapy. Taken together, these results indicated that helvolic acid in combination with CTX showed potent in vivo synergistic antitumor efficacy, and its mechanism of actionmay involve the Wnt/β-catenin signaling pathway.
- Publication
Experimental Biology & Medicine, 2017, Vol 242, Issue 2, p214
- ISSN
1535-3702
- Publication type
Article
- DOI
10.1177/1535370216668051