We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Crossing paths: interactions between the cell death machinery and growth factor survival signals.
- Authors
Brumatti, Gabriela; Salmanidis, Marika; Ekert, Paul G.
- Abstract
Cytokines and growth factors play a crucial role in the maintenance of haematopoietic homeostasis. They transduce signals that regulate the competing commitments of haematopoietic stem cells, quiescence or proliferation, retention of stem cell pluripotency or differentiation, and survival or demise. When the balance between these commitments and the requirements of the organisms is disturbed, particularly when it favours survival and proliferation, cancer may result. Cell death provoked by loss of growth factor signalling is regulated by the Bcl-2 family of apoptosis regulators, and thus survival messages transduced by growth factors must regulate the activity of these proteins. Many aspects of direct interactions between cytokine signalling and regulation of apoptosis remain elusive. In this review, we explore the mechanisms by which cytokines, in particular Interleukin-3 and granulocyte–macrophage colony-stimulating factor, promote cell survival and suppress apoptosis as models of how cytokine signalling and apoptotic pathways intersect.
- Subjects
CYTOKINES; GROWTH factors; APOPTOSIS; HEMATOPOIESIS; CARCINOGENESIS
- Publication
Cellular & Molecular Life Sciences, 2010, Vol 67, Issue 10, p1619
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-010-0288-8