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- Title
Rheumatoid Arthritis and Interleukin-32.
- Authors
Shoda, H.; Fujio, K.; Yamamoto, K.
- Abstract
The inflammatory cytokine cascade plays a pivotal role in the pathogenesis of rheumatoid arthritis. Recently, a novel human cytokine, interleukin-32, was reported to induce tumor necrosis factor (TNF)-α. Interleukin-32 is expressed primarily in lymphoid tissues and leukocytes, but also in stimulated epithelial cells and synovial fibroblasts. Although the interleukin-32 receptor has not been reported, interleukin-32 can induce other inflammatory cytokines such as TNF-α, interleukin-1β, and interleukin-6 from monocytes/macrophages in vitro and in vivo, and it synergizes with signals from pattern-recognition receptors. Notably, in the inflamed synovial tissues from rheumatoid arthritis patients, interleukin-32 is prominently expressed and correlates with the severity of arthritis and the expression of other cytokines, including TNF-α and interleukin-1. In experimental mice models of arthritis, joint injection of interleukin-32 induces joint inflammation, and overexpression of interleukin-32β in hematopoietic cells exacerbates collagen-induced arthritis. Interleukin-32 can thus be seen to play an important role in the pathogenesis of rheumatoid arthritis.
- Subjects
RHEUMATOID arthritis; CYTOKINES; INTERLEUKINS; TUMOR necrosis factors; LEUCOCYTES
- Publication
Cellular & Molecular Life Sciences, 2007, Vol 64, Issue 19/20, p2671
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-007-7186-8