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- Title
Complex Propagation Patterns Characterize Human Cortical Activity during Slow-Wave Sleep.
- Authors
Hangya, Balázs; Tihanyi, Benedek T.; Entz, László; Fabó, Dániel; ErŐss, Loránd; Wittner, Lucia; Jakus, Rita; Varga, Viktor; Freund, Tamás F.; Ulbert, István
- Abstract
Cortical electrical activity during nonrapid eye movement (non-REM) sleep is dominated by slow-wave activity (SWA). At larger spatial scales (∼2-30 cm), investigated by scalp EEG recordings, SWA has been shown to propagate globally over wide cortical regions as traveling waves, which has been proposed to serve as a temporal framework for neural plasticity. However, whether SWA dynamics at finer spatial scales also reflects the orderly propagation has not previously been investigated in humans. To reveal the local, finer spatial scale (∼1- 6 cm) patterns of SWA propagation during non-REM sleep, electrocorticographic (ECoG) recordings were conducted from subdurally implanted electrode grids and a nonlinear correlation technique [mutual information (MI)] was implemented. MI analysis revealed spatial maps of correlations between cortical areas demonstratingSWApropagation directions, speed, and association strength. Highest correlations, indicating significant coupling, were detected during the initial positive-going deflection of slow waves. SWA propagated predominantly between adjacent cortical areas, albeit spatial noncontinuities were also frequently observed. MI analysis further uncovered significant convergence and divergence patterns. Areas receiving the most convergent activity were similar to those with high divergence rate, while reciprocal and circular propagation ofSWAwas also frequent.Wehypothesize thatSWAis characterized by distinct attributes depending on the spatial scale observed. At larger spatial scales, the orderly SWA propagation dominates; at the finer scale of the ECoG recordings, non-REM sleep is characterized by complex SWA propagation patterns.
- Subjects
EYE movements; CONVERGENT evolution; NEUROPLASTICITY; BIOLOGICAL divergence; RAPID eye movement sleep
- Publication
Journal of Neuroscience, 2011, Vol 31, Issue 24, p8770
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.1498-11.2011