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- Title
Transcriptomic Analysis of Livers of Inactive Carriers of Hepatitis B Virus With Distinct Expression of Hepatitis B Surface Antigen.
- Authors
Montanari, Noe Rico; Ramirez, Ricardo; Buuren, Nick Van; Bosch, Thierry P P van den; Doukas, Michail; Debes, Jose D; Feierbach, Becket; Boonstra, Andre; Rico Montanari, Noe; Van Buuren, Nick; van den Bosch, Thierry P P
- Abstract
Inactive carrier phases in chronic hepatitis B virus (HBV) infection present minimal liver disease and HBV replication activity suggesting partial immune reconstitution, although the mechanisms responsible remain elusive. Moreover, hepatitis B surface antigen (HBsAg) production-hypothesized to modulate the immune response-is unaltered. In the current study, we assessed the intrahepatic transcriptome in inactive carriers of HBV versus healthy liver donors, including in the context of diverse HBsAg levels (serum and liver), to better understand the phenomenon of immune control. We found a deregulated liver transcriptome in inactive carriers compared with healthy controls, despite normal liver function. Moreover, diverse HBsAg levels have minimal impact on the liver transcriptome in inactive carriers, although gene correlation analysis revealed that leukocyte activation, recruitment, and innate responses genes were correlated with liver HBsAg levels. These findings provide more insight into the mechanisms underlying anti-HBV strategies currently under development, aimed at interfering with HBsAg production or inducing a state of immune control.
- Subjects
HEPATITIS associated antigen; HEPATITIS B virus; LIVER analysis; CHRONIC hepatitis B; TRANSCRIPTOMES; HEPATITIS B; VIRAL antigens; RESEARCH; DNA; LIVER; RESEARCH methodology; HEPATITIS viruses; EVALUATION research; COMPARATIVE studies; GENE expression profiling; CARRIER state (Communicable diseases)
- Publication
Journal of Infectious Diseases, 2022, Vol 225, Issue 6, p1081
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiab381