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- Title
Diagnostic Value of Anti-GBV-C Antibodies in HIV-Infected Patients.
- Authors
Gómara, Maria J.; Fernández, Leticia; P#x00E9;rez, Teresa; Tenckhoff, Solveig; Casanovas, Aurora; Tillmann, Hans L.; Haro, Isabel
- Abstract
The beneficial effect of co-infection by GB virus C (GBV-C) in the course of the disease in human immunodeficiency virus (HIV)-infected patients has been described, although its mechanism of action is yet to be determined. The role of anti-GBV-C antibodies in HIV-infected patients also remains unknown. At present, there are no commercial systems to detect specific markers of GBV-C infection. The research presented follows our previous work from which we obtained chimeric molecules formed by two domains of different GBV-C proteins with good sensitivity ⁄ specificity balances in the detection of anti-GBV C antibodies in hemodialyzed and chronic hepatitis patient samples. It has been investigated the ability of the synthetic peptides to recognize specific anti-GBVC antibodies in HIV and HCV⁄ HIV co-infected patients by a peptide-based ELISA immunoassay. The results showed that human immunodeficiency virus-infected patients have a significantly higher frequency of anti-GBV-C antibodies than healthy controls. A comparison between HCV+ ⁄ HIV+ and HCV) ⁄ HIV+ was analyzed. Although a higher percentage of HCV⁄ HIV-positive sera were positive for antibodies against GBV-C peptides, the difference was not significant. The presence of anti- GBV-C antibodies could represent a good marker of exposure to GBV-C in HIV infected patients to facilitate a further analysis of the effect of this exposure in the progression of illness caused by HIV infection.
- Subjects
HIV-positive persons; ENZYME-linked immunosorbent assay; ALANINE aminotransferase; ASPARTATE aminotransferase; HIGHLY active antiretroviral therapy
- Publication
Chemical Biology & Drug Design, 2011, Vol 78, Issue 2, p277
- ISSN
1747-0277
- Publication type
Article
- DOI
10.1111/j.1747-0285.2011.01143.x