We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Performance of hydroxyapatite bone repair scaffolds created via three-dimensional fabrication techniques.
- Authors
Tithi Dutta Roy; Joshua L. Simon; John L. Ricci; E. Dianne Rekow; Van P. Thompson
- Abstract
The current study analyzes the in vivo performance of porous sintered hydroxyapatite (HA) bone repair scaffolds fabricated using the TheriForm solid freeform fabrication process. Porous HA scaffolds with engineered macroscopic channels had a significantly higher percentage of new bone area compared with porous HA scaffolds without channels in a rabbit calvarial defect model at an 8-week time point. An unexpected finding was the unusually large amount of new bone within the base material structure, which contained pores less than 20 μm in size. Compared with composite scaffolds of 80% polylactic-co-glycolic acid and 20% β-tricalcium phosphate with the same macroscopic architecture as evaluated in a previous study, the porous HA scaffolds with channels had a significantly higher percentage of new bone area. Therefore, the current study indicates that scaffold geometry, as determined by the fabrication process, can enhance the ability of a ceramic material to accelerate healing of calvarial defects. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 67A: 12281237, 2003
- Subjects
HYDROXYAPATITE; BONES; TISSUE engineering; CALCIUM phosphate
- Publication
Journal of Biomedical Materials Research, Part A, 2003, Vol 67, Issue 4, p1228
- ISSN
1549-3296
- Publication type
Article
- DOI
10.1002/jbm.a.20034