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- Title
Genetics of Cisplatin Ototoxicity: Confirming the Unexplained?
- Authors
Boddy, A V
- Abstract
Replication of findings in clinical pharmacogenetic studies is essential but often neglected. The observation that TPMT and COMT genotypes, in combination with ABCC3 genotype, are predictive of ototoxicity following cisplatin treatment has been confirmed. However, translating this observation into a useful preventive strategy requires more mechanistic insight.
- Subjects
PHARMACOGENOMICS; OTOTOXICITY; CISPLATIN; RETINOBLASTOMA; CARBOPLATIN
- Publication
Clinical Pharmacology & Therapeutics, 2013, Vol 94, Issue 2, p198
- ISSN
0009-9236
- Publication type
Article
- DOI
10.1038/clpt.2013.116