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- Title
The Effect of Nonsurgical Periodontal Therapy on the Level of Human Neutrophil Peptides 1-3 in Patients with Aggressive Periodontitis.
- Authors
Dolińska, Ewa; Skurska, Anna; Dymicka-Piekarska, Violetta; Milewski, Robert; Pietruski, Jan; Pietruska, Małgorzata; Sculean, Anton
- Abstract
<bold>Purpose: </bold>To assess the presence of HNP1-3 in the gingival crevicular fluid (GCF) of patients suffering from aggressive periodontitis before and after nonsurgical periodontal therapy.<bold>Materials and Methods: </bold>Twenty patients, each with generalised aggressive periodontitis (GAP) were included in the study. After periodontal examination, one site with a probing depth (PD) ≥ 4 mm was selected. Patients received nonsurgical treatment (scaling and root planing [SRP]) with additional administration of systemic antibiotic therapy (amoxicillin 375 mg three times daily + metronidazole 250 mg three times daily for 7 days). Prior to therapy and 3 and 6 months after, the following parameters were evaluated from the same site: PD, gingival recession (GR), clinical attachment level (CAL), plaque index (PI), bleeding on probing (BOP), sulcus fluid flow rate (SFFR). The level of HNP1-3 in GCF was determined by means of a commercially available ELISA kit.<bold>Results: </bold>Compared to baseline, the level of HNP 1-3 did not show statistically significant differences at 3 and 6 months. The evaluated clinical parameters and SFFR showed statistically significant decreases compared to baseline. At 6 months, PD (median) decreased from 7 to 3.5 and CAL (median) decreased from 7 to 4.<bold>Conclusion: </bold>In patients with GAP, nonsurgical periodontal therapy in conjunction with systemic administration of amoxicillin and metronidazole had no effect on the level of HNP1-3 in GCF.
- Subjects
AGGRESSIVE periodontitis; NEUTROPHILS; PERIODONTAL disease; ANTIBIOTICS; GINGIVAL recession; PATIENTS; THERAPEUTICS; AMOXICILLIN; METRONIDAZOLE; PERIODONTITIS treatment; DENTAL scaling; ENZYME-linked immunosorbent assay; EXUDATES &; transudates; PEPTIDES; PERIODONTICS; PERIODONTITIS; TOOTH root planing; TREATMENT effectiveness
- Publication
Oral Health & Preventive Dentistry, 2017, Vol 15, Issue 6, p557
- ISSN
1602-1622
- Publication type
journal article
- DOI
10.3290/j.ohpd.a38995