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- Title
Circulating Chemerin Is Elevated in Women With Preeclampsia.
- Authors
Bartho, Lucy A; Kandel, Manju; Walker, Susan P; Cluver, Catherine A; Hastie, Roxanne; Bergman, Lina; Pritchard, Natasha; Cannon, Ping; Nguyen, Tuong-Vi; Wong, Georgia P; MacDonald, Teresa M; Keenan, Emerson; Hannan, Natalie J; Tong, Stephen; Kaitu'u-Lino, Tu'uhevaha J
- Abstract
Background: Preeclampsia is a severe complication of pregnancy. Chemerin is an adipokine secreted from adipose tissue and highly expressed in placenta. This study evaluated the biomarker potential of circulating chemerin to predict preeclampsia. Methods: Maternal plasma and placenta were collected from women with early-onset preeclampsia (<34 weeks), with preeclampsia and eclampsia, or before preeclampsia diagnosis (36 weeks). Human trophoblast stem cells were differentiated into syncytiotrophoblast or extravillous trophoblasts across 96 hours. Cells were cultured in 1% O2 (hypoxia) or 5% O2 (normoxia). Chemerin was measured by enzyme-linked immunosorbent assay (ELISA) and RARRES2 (gene coding chemerin) by reverse transcription-quantitative polymerase chain reaction. Results: Circulating chemerin was increased in 46 women with early-onset preeclampsia (<34 weeks) compared to 17 controls (P <.0006). Chemerin was increased in placenta from 43 women with early-onset preeclampsia compared to 24 controls (P <.0001). RARRES2 was reduced in placenta from 43 women with early-onset preeclampsia vs 24 controls (P <.0001). Chemerin was increased in plasma from 26 women with established preeclampsia (P =.006), vs 15 controls. Circulating chemerin was increased in 23 women who later developed preeclampsia vs 182 who did not (P = 3.23 × 10−6). RARRES2 was reduced in syncytiotrophoblast (P =.005) or extravillous trophoblasts (P <.0001). Hypoxia increased RARRES2 expression in syncytiotrophoblast (P =.01) but not cytotrophoblast cells. Conclusions: Circulating chemerin was elevated in women with early-onset preeclampsia, established preeclampsia, and preceding preeclampsia diagnosis of preeclampsia. RARRES2 was dysregulated in placenta complicated by preeclampsia and may be regulated through hypoxia. Chemerin may have potential as a biomarker for preeclampsia but would need to be combined with other biomarkers.
- Subjects
PREECLAMPSIA; PREGNANT women; TROPHOBLAST
- Publication
Endocrinology, 2023, Vol 164, Issue 5, p1
- ISSN
0013-7227
- Publication type
Article
- DOI
10.1210/endocr/bqad041